Electrochemical evaluation of nivolumab used in cancer treatment with differential pulse voltammetry: A novel approach with single-use pencil graphite electrode.

Objectives: Nivolumab is used in a treatment called immunotherapy, which helps the immune system cells to attack cancer cells. The electrochemical properties and quantification of this drug were performed using single-use pencil tips.

Evidence Acquisition: Here, a selective voltammetric method for the determination and electrochemical characterization of Nivolumab used in cancer therapy was developed for the first time using a disposable pencil electrode by cyclic voltammetry and differential pulse voltammetry techniques.

Quantitative determination and removal of pesticide residues in fresh vegetables and fruit products by LC-MS/MS and GC-MS/MS.

Pesticides are the potent agrochemicals used to successfully manage, repel, or stop pests and weeds in agricultural production. This study analyzed 222 pesticide active substances in 90 samples of seven different vegetables and fruits acquired from producers through liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) and gas chromatography-mass spectrometry/mass spectrometry (GC-MS/MS) technology. The validation parameters of each pesticide's active substances were determined.

A new method to reduce false positives due to antimony in detection of gunshot residues.

False positives due to the presence of antimony in vehicle seat fabrics are a problem in gunshot residue (GSR) analysis, in particular, when graphite furnace atomic absorption spectrometry (GFAAS) is employed. In this study, we sought to determine the reason for the prevalence of false positive results and to propose a new approach for the analysis of GSR on vehicle seats. GFAAS was used to examine adhesive tape swabs collected from 100 seats of 50 different automobiles.

Phosphorus speciation in the surface sediment and river water from the Orontes (Asi) River, Turkey.

The paper presents the results of the distribution of phosphorus bioavailability (total, organic, and inorganic phosphorus) in surface sediment and river water from the Orontes (Asi) River (Samandag, Antakya, Turkey) in March 2008. Speciation of inorganic phosphorus was carried out using a method on sequential extractions, with each releasing four forms of inorganic phosphorus-loosely sorbed phosphorus, phosphorus bound to aluminum (P-AL), phosphorus bound to iron (P-Fe), and phosphorus bound to calcium (P-Ca). Total phosphorus concentrations are, on average, 3.

A sequential extraction to determine the distribution of phosphorus in the seawater and marine surface sediment.

The distribution of phosphorus species among environmental compartments (e.g., between water and sediment), significantly affects the bioavailability of these species to organisms.

Synthesis and monoamine oxidase inhibitory activities of 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-1H-pyrazole derivatives.

Ten new 1-thiocarbamoyl-3-(phenyl and/or 4-substituted phenyl)-5-(3,4-dimethoxyphenyl and/or 2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole derivatives were synthesized by reacting 1,3-diphenylpropen-1-ones and thiosemicarbazide. The chemical structures of the compounds were verified by means of their IR, 1H-NMR, ESI-MS spectroscopic data and elementary analyses. All the compounds were investigated for their ability to selectively inhibit monoamine oxidase (MAO) by in-vitro tests.

Effects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cells.

Recent evidence indicates that boron and borates may have anticarcinogenic properties. In this study, we have investigated the incidence of adverse cytological findings in cervical smears and the micronucleus (MN) frequency in women living in boron-rich and boron-poor regions. Cervical smears were prepared from 1059 women with low socioeconomic status; 472 of the women lived in relatively boron-rich rural areas, while 587 lived in relatively boron-poor regions.