Publications by authors named "Ezinwanne Nneoma Ezeibe"
Article Synopsis
- * Preventive measures, such as social distancing and mask-wearing, have helped slow the virus's spread; however, the persistent nature of the virus and its variants makes complete eradication difficult.
- * The development of effective vaccines relies heavily on nanotechnology, which enhances vaccine delivery and efficacy; currently, four vaccines are approved for use, with more in progress.
Background: Artemether and lumefantrine display low aqueous solubility leading to poor release profile; hence the need for the use of lipid-based systems to improve their oral bioavailability so as to improve their therapeutic efficacy.
Aim And Objective: The objective of this work was to utilize potentials of nanostructured lipid carriers (NLCs) for improvement of the oral bioavailability of artemether and lumefantrine combination and to evaluate its efficacy in the treatment of malaria. This study reports a method of formulation, characterization and evaluation of the therapeutic efficacies of caprol-based NLC delivery systems with artemether and lumefantrine.