Publications by authors named "Ezequiel Hernan Calvo Roitberg"
Tumor cell migration and invasion into adjacent tissues is one of the hallmarks of cancer and the first step towards secondary tumors formation, which represents the leading cause of cancer-related deaths. This process is considered an unmet clinical need in the treatment of this disease, particularly in breast cancers characterized by high aggressiveness and metastatic potential. To identify and characterize genes with novel functions as regulators of tumor cell migration and invasion, we performed a genetic loss-of-function screen using a shRNA library directed against the Ubiquitin Proteasome System (UPS) in a highly invasive breast cancer derived cell line.
View Article and Find Full Text PDFArticle Synopsis
- Tumor cell spread significantly decreases survival and quality of life in cancer patients.
- Dysregulation of the ubiquitination pathway contributes to the aggressive behavior of tumor cells, presenting it as a potential target for treatment.
- The study identified USP19 as a key player in promoting tumor cell invasion and migration, suggesting it could serve as a novel therapeutic target in breast cancer.