Publications by authors named "Ezeofor Victory"
Background: In the United Kingdom, it is estimated that 5,000 patients sustain eye injuries or ocular trauma requiring hospital admission annually, of which 250 patients will be permanently blinded. This study explores the cost-effectiveness of Adjunctive Steroid Combination in Ocular Trauma (ASCOT) given during surgery versus standard treatment in vitreoretinal surgery in patients with open globe trauma.
Methods: This economic evaluation was embedded alongside the ASCOT RCT (ClinicalTrials.
Background: Eyes sustaining open globe trauma are at high risk of severe visual impairment. Proliferative vitreoretinopathy is the most common cause of retinal detachment and visual loss in eyes with open globe trauma. There is evidence from experimental studies and pilot clinical trials that the use of adjunctive steroid medication triamcinolone acetonide can reduce the incidence of proliferative vitreoretinopathy and improve outcomes of surgery for open globe trauma.
View Article and Find Full Text PDFObjective: To determine the effectiveness of an exercise and functional activity therapy intervention in adults with early dementia or mild cognitive impairment compared with usual care.
Design: Randomised controlled trial.
Setting: Participants' homes and communities at five sites in the United Kingdom.
Introduction: Just under half of patients with obstructive sleep apnoea (OSA) also have gastro-oesophageal reflux disease (GORD). These conditions appear to be inter-related and continual positive airway pressure (CPAP) therapy, the gold standard treatment for OSA to prevent airway collapse, has been shown to reduce GORD. As the impact of mandibular advancement devices, a second-line therapy for OSA, on GORD has yet to be investigated, a feasibility study is needed prior to a definitive trial.
View Article and Find Full Text PDFPrevention of postpartum haemorrhage: Economic evaluation of the novel butterfly device in a UK setting.
Eur J Obstet Gynecol Reprod Biol
April 2023
Objectives: To explore the cost-effectiveness of a novel PPH device as compared with usual care.
Design: A decision analytical model was used to explore the cost-effectiveness of the PPH Butterfly device compared with usual care. This was part of a United Kingdom, UK, clinical trial ISRCTN15452399 using a matched historical cohort who had standard PPH management without the use of the PPH Butterfly device.
Background/aims: To investigate the clinical effectiveness of adjunctive triamcinolone acetonide (TA) given at the time of vitreoretinal surgery following open globe trauma (OGT).
Methods: A phase 3, multicentre, double-masked randomised controlled trial of patients undergoing vitrectomy following OGT comparing adjunctive TA (intravitreal and subtenons) against standard care (2014-2020). The primary outcome was the proportion of patients with at least 10 Early Treatment Diabetic Retinopathy Study (ETDRS) letter improvement in corrected visual acuity (VA) at 6 months.
A mixed method, phase 2 clinical evaluation of a novel device to treat postpartum haemorrhage.
Eur J Obstet Gynecol Reprod Biol
April 2023
Background: We evaluated the safety, efficacy, and acceptability of a new device designed to facilitate uterine compression in women with postpartum haemorrhage (PPH).
Methods: A prospective, phase two clinical device trial with concurrent qualitative study, conducted in a UK consultant obstetric unit. The device was used in addition to standard care in women unresponsive to initial oxytocin therapy.
Article Synopsis
- People with rarer dementias struggle to find support and tailored information, but online meeting platforms can help them connect, especially during the COVID-19 pandemic.
- The study focuses on creating videoconferencing support groups for individuals with frontotemporal dementia, young-onset Alzheimer’s, and other conditions, detailing the process of development, testing, and evaluation.
- A three-phase approach was used to gather input from affected individuals, test the support groups with 154 participants, and develop an evaluation plan to refine future sessions based on gathered data and themes.
Background: The formation of dental caries is the most common chronic disease in children, and is preventable. The oral health-related quality of life has an immense impact on an individual's daily functioning, well-being or overall quality of life.
Objectives: This study aims to investigate the cost effectiveness of the Dental RECUR Brief Negotiated Interview for Oral Health (DR-BNI).
Article Synopsis
- The head and neck cancer Patient Concerns Inventory (PCI) helps patients express concerns to healthcare providers that may otherwise be missed, aiming to improve treatment discussions.
- This study is the first economic evaluation of the PCI in HNC patients, focusing on the costs and effects of prioritizing treatment pathways beyond just the main cancer treatment, with implications for global health policy.
- Data from 191 patients showed that the PCI was low-cost (~£13) and cost-effective, leading to better quality-adjusted life years (0.79 vs. 0.76 in non-PCI), thus supporting its use in clinical practice for better patient outcomes and reduced overall costs.
Background: Critical limb ischaemia is a severe stage of lower limb peripheral artery disease which can lead to tissue loss, gangrene, amputation and death. FlowOx™ therapy is a novel negative-pressure chamber system intended for home use to increase blood flow, reduce pain and improve wound healing for patients with peripheral artery disease and critical limb ischaemia.
Methods: A Markov model was constructed to assess the relative cost-effectiveness of FlowOx™ therapy compared to standard care in lower limb peripheral artery disease patients with intermittent claudication or critical limb ischaemia.
Protocol for the Rare Dementia Support Impact study: RDS Impact.
Int J Geriatr Psychiatry
August 2020
Article Synopsis
- The Rare Dementia Support (RDS) Impact study is the first significant investigation into the effectiveness of multicomponent support groups for individuals living with rare forms of dementia and their caregivers, conducted through multiple research work packages.
- The study employs a mixed-methods design and aims to involve over 1000 participants, using both quantitative and qualitative approaches, including cohort interviews and randomized controlled trials to assess the outcomes and develop innovative measures.
- Data collection for the study started in January 2020, and it seeks to explore the concept of "impact" through longitudinal data gathering, novel creative methods, and health economic analyses, all aimed at improving support for those affected by rare dementias.