Publications by authors named "Eyob A Mesfin"
Background: Ethiopia is one of the high multidrug-resistant tuberculosis (MDR-TB) burden countries. However, phenotypic drug susceptibility testing can take several weeks due to the slow growth of Mycobacterium tuberculosis complex (MTBC) strains. In this study, we assessed the performance of a Sanger sequencing approach to predict resistance against five anti-tuberculosis drugs and the pattern of resistance mediating mutations.
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- The study focuses on complex Mycobacterium tuberculosis Lineage 3 (L3) strains, which are prevalent in regions with high tuberculosis rates, analyzing 2682 strains from 38 countries.
- Researchers used advanced techniques like MIRU-VNTR genotyping and whole-genome sequencing to explore the genetic diversity and population structure of L3 strains across five continents.
- Findings indicate that L3 strains originated in Southern Asia and later spread to North-East and East Africa, offering insights that could aid in the development of new treatments and vaccines for tuberculosis.
Background: Multidrug drug-resistant tuberculosis (MDR-TB) is a major health problem and seriously threatens TB control and prevention efforts globally. Ethiopia is among the 30th highest TB burden countries for MDR-TB with 14% prevalence among previously treated cases. The focus of this study was on determining drug resistance patterns of Mycobacterium tuberculosis among MDR-TB suspected cases and associated risk factors.
View Article and Find Full Text PDFBackground: Quality laboratory service is an essential component of health care system but in Sub-Saharan Africa such as Ethiopia, laboratories quality system remains weak due to several factors and it needs more attention to strengthen its capacity and quality system.
Methodology: A cross sectional study was conducted using a questionnaire to assess factors affecting the quality of laboratory service at private and public health institutions in Addis Ababa.
Results: A total of 213 laboratory professionals participated in the study and 131 (61.
Introduction: The World Health Organization Regional Office for Africa (WHO AFRO) introduces a step wise incremental accreditation approach to improving quality of laboratory and it is a new initiative in Ethiopia and activities are performed for implementation of accreditation program.
Methods: Descriptive cross sectional study was conducted in 30 laboratory facilities including 6 laboratory sections to determine their status towards of accreditation using WHO AFRO accreditation checklist and 213 laboratory professionals were interviewed to assess their knowledge on quality system essentials and accreditation in Addis Ababa Ethiopia.
Results: Out of 30 laboratory facilities 1 private laboratory scored 156 (62%) points, which is the minimum required point for WHO accreditation and the least score was 32 (12.