Publications by authors named "Eymeric Lagonotte"
Epithelial-to-mesenchymal transition (EMT) is believed to contribute to tumour invasion. Vimentin expression by carcinoma cells is a largely recognized marker of EMT. This study aimed at examining vimentin expression in non small cell lung carcinomas (NSCLC) by immunohistochemistry to evaluate potential correlations between vimentin expression and the differentiation status, the TNM stage and the outcome of the patients.
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- This study investigated the clinical and histological characteristics of five patients suffering from thrombotic microangiopathy (TMA) associated with sirolimus, a common immunosuppressant.
- The findings indicated that sirolimus-induced TMA is especially likely to occur in kidneys with existing endothelial damage, observed in patients facing acute and chronic rejection while off calcineurin inhibitors.
- Notably, the study revealed that renal expression of vascular endothelial growth factor (VEGF) was significantly lower in cases of sirolimus-induced TMA compared to healthy transplanted kidneys, suggesting that sirolimus treatment may contribute to reduced VEGF levels, which could enhance the risk of developing TMA.