Publications by authors named "Eylem Kulkoyluoglu"
Article Synopsis
- Many breast cancer deaths come from women with recurrent, estrogen receptor-positive tumors, highlighting the need for new treatment methods to make these tumors more sensitive to endocrine therapies.
- This study focused on validating certain nuclear transport genes, particularly XPO1, as potential indicators of endocrine therapy failure and explored how inhibiting XPO1 could enhance endocrine treatments.
- Results indicated that high levels of XPO1 were linked to poor survival rates and tamoxifen resistance, but combining XPO1 inhibition with tamoxifen restored sensitivity and reduced recurrence in resistant cancer models.
Estrogens regulate function of reproductive and non-reproductive tissues in healthy and diseased states including breast cancer. They mainly work through estrogen receptor alpha (ERα) and/or estrogen receptor beta (ERβ). There are various ERα targeting agents that have been used for treatment of ER (+) breast tumors.
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