The dual modulatory effect of folic acid supplementation on indomethacin-induced gastropathy in the rat.

Background/aims: Folic acid modulates several disorders in humans. We investigated the effects of folic acid supplementation at varying doses on ulcer formation in the rat.

Materials And Methods: Male Wistar rats were treated with 1 mg/kg, 2 mg/kg and 3 mg/kg diet of folic acid for 21 days.