[Short-term effects of gamma-globulins on sleep organization in epileptic patients (author's transl)].

A study of the effect of gamma-globulins on sleep was conducted in 8 patients aged 1 to 35 years with epilepsy not responding to any of the conventional treatments. Two polygraphic recordings were carried out during the 4th and 5th nights following a placebo injection and then an injection of gamma-globulin 16 Merieux (1 ml/kg). The short-term effects of the gamma-globulins were : --reduction in percentage of paroxysms, --an acceleration in the electroencephalographic tracings of the different stages of sleep and those of the waking period, --a statistically significant increase in the percentage of paradoxical sleep, though the general organization of sleep remained unchanged.

[The effects of gammaglobulins in resistant epilepsies. A preliminary study (author's transl)].

The effect of injections of gammaglobulins 16 Mérieux (1 ml/kg) was studied in 9 patients aged from 1 to 35 years suffering from epilepsy resistant to conventional anticonvulsant treatment. Different types of epilepsy were studied to try to discover a possible indication as a function of the type of epilepsy. Results were assessed according to the patients' behaviour, the frequency and severity of clinical fits, the results of psychological tests, and EEG tracing recorded over long periods of time.