Publications by authors named "Eyal Zoler"
Article Synopsis
- Janus kinases (JAKs) play a crucial role in regulating signaling and gene transcription by binding to class I and II cytokine receptors, particularly in the context of type I interferons (IFNs).
- Research showed that modified IFNARs maintain similar IFN signaling levels, while specific versions of IFNAR2 perform poorly despite having necessary docking sites for JAKs and STATs.
- JAKs exhibit promiscuous binding to various cytokine receptors, influencing cross-phosphorylation and signaling efficiency, which contributes to the different signaling outcomes observed in different cell types.
SARS-CoV-2 variants of interest and concern will continue to emerge for the duration of the COVID-19 pandemic. To map mutations in the receptor-binding domain (RBD) of the spike protein that affect binding to angiotensin-converting enzyme 2 (ACE2), the receptor for SARS-CoV-2, we applied in vitro evolution to affinity-mature the RBD. Multiple rounds of random mutagenic libraries of the RBD were sorted against decreasing concentrations of ACE2, resulting in the selection of higher affinity RBD binders.
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