Publications by authors named "Eyal Bitton"
Article Synopsis
- Information in the brain is transmitted via neurotransmitters released from long-range axons, and understanding this activity is crucial for linking brain function to behavior.* -
- Current chemogenetic and optogenetic tools for manipulating these connections have limitations in sensitivity and precision.* -
- The study identifies the ciliary opsin from Platynereis dumerilii (PdCO) as a highly effective tool for optogenetics, allowing precise control and reversible loss-of-function experiments in mammalian neurons and enabling detailed mapping of brain circuits in live animals.*
Information is transmitted between brain regions through the release of neurotransmitters from long-range projecting axons. Understanding how the activity of such long-range connections contributes to behavior requires efficient methods for reversibly manipulating their function. Chemogenetic and optogenetic tools, acting through endogenous G-protein coupled receptor (GPCRs) pathways, can be used to modulate synaptic transmission, but existing tools are limited in sensitivity, spatiotemporal precision, or spectral multiplexing capabilities.
View Article and Find Full Text PDFInformation is carried between brain regions through neurotransmitter release from axonal presynaptic terminals. Understanding the functional roles of defined neuronal projection pathways requires temporally precise manipulation of their activity. However, existing inhibitory optogenetic tools have low efficacy and off-target effects when applied to presynaptic terminals, while chemogenetic tools are difficult to control in space and time.
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