Sorsby's fundus dystrophy.

Ever since Sorsby described his pseudoinflammatory dystrophy in five families, its characteristics have been unclear. The findings in ten affected members of a seven-generation pedigree are discussed and the literature is reviewed. Patients with this dominantly inherited fundus dystrophy lose central vision between the second and fourth decade of life.

Comparison of flagging, walking, trapping, and collecting from hosts as sampling methods for northern deer ticks, Ixodes dammini, and lone-star ticks, Amblyomma americanum (Acari:Ixodidae).

Ticks were sampled by flagging, collecting from the investigator's clothing (walking samples), trapping with dry-ice bait, and collecting from mammal hosts on Fire Island, NY, U.S.A.

HydroLink gel electrophoresis (HLGE). III. High DNA loading capacity and recovery of dsDNA.

Novel polymers have been prepared for high performance electrophoretic separations of double-stranded DNA (dsDNA). These materials are part of a family of HydroLink high performance electrophoresis polymers. A comparison of the resolving capabilities of dsDNA HydroLink gels to agarose and polyacrylamide separations has been described in an accompanying paper.

HydroLink gel electrophoresis (HLGE). II. Applications of a new polymer matrix to dsDNA analysis.

HydroLink materials represent a novel family of gels composed of unique polymer matrices. The applications of HydroLink to molecular biology and, specifically, to DNA technology have been carefully investigated. Our results indicate that the HydroLink matrix developed for double-stranded DNA (dsDNA) is an excellent tool for electrophoretic separations in fixed electric fields.

Habitat distribution of Ixodes dammini (Acari: Ixodidae) an Lyme disease spirochetes on Fire Island, New York.

The distributions of Ixodes dammini Spielman, Clifford, Piesman, and Corwin and Lyme disease spirochetes were studied on Fire Island, N.Y. Adult ticks were more common in high-shrub habitats (shrubby vegetation greater than or equal to 1 m high) than in grassy and lowshrub habitats (vegetation less than 1 m) in spring and fall.

Atopic eczema and preterm birth.

In a group of 443 children with atopic eczema there was a significant lack of subjects born before 37 weeks' gestation. It is possible that preterm birth reduces the chances of the subsequent development of severe atopic disease.

The use of law for prevention in the public interest.

One of the most important functions of law and the legal system is to prevent harm by regulating conduct prospectively. Almost all law--whether in the form of a statute enacted by a legislative body or a judgment decreed by a court--is designed, at least in part, to avoid some socially undesirable future state of affairs. This chapter explores some of the more significant ways in which lawmaking (both legislative and judicial) may be regarded as a form of prevention and the legal system may be used for prevention in the public interest.

The erasable Western blot.

A method for successfully removing primary and secondary antibodies from nitrocellulose blots while preserving the originally immobilized polypeptides was developed. Polypeptides were separated by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate and electrophoretically transferred to nitrocellulose. Nonspecific binding sites were blocked with 5% (w/v) nonfat dried milk.

The use of galactosyltransferase to probe nitrocellulose-immobilized glycoproteins for nonreducing terminal N-acetylglucosamine residues.

We report the use of UDPgalactose:N-acetyl-D-glucosaminyl-glycopeptide 4-beta-D-galactosyl-transferase (EC 2.4.1.

Congenital hereditary (juvenile X-linked) retinoschisis. Histopathologic and ultrastructural findings in three eyes.

One surgically enucleated and two postmortem eyes were obtained from two related men with congenital hereditary retinoschisis. A periodic acid-Schiff-positive amorphous material was identified within the retina adjacent to the schisis cavities. Ultrastructural examination of this material showed numerous extracellular filaments, measuring approximately 11 nm in diameter.

Early congenital syphilis still occurs.

Seven cases of early congenital syphilis have been recorded in the past 10 years in the Mersey Regional Health Authority. Antenatal serology was initially negative in five mothers, who were either incubating or acquired the infection later, and treatment had probably failed in two women given erythromycin for syphilis during pregnancy. Serology should be repeated later in pregnancy in those at high risk.

Fatal hepatitis B in infant born to a HBsAg carrier with HBeAb.

Fulminant hepatic failure occurred in an 11 week old baby of a Caucasian mother who was hepatitis B surface antigen positive, B e antigen negative, and B e antibody positive. Infants of hepatitis B e antigen positive mothers receive immunoprophylaxis against hepatitis, unlike those born to mothers who are B e antibody positive.

Evoked potential studies of the effects of impact acceleration on the motor nervous system.

The initial results of a continuing investigation into the effects of various levels of impact acceleration on the functional integrity of the motor nervous system are summarized. The results are based on the measurement of alterations in neural transmission along the motor pathway of the Rhesus monkey as revealed by latency and amplitude changes in the motor pathway evoked potential (EP) following the delivery of various levels of impact acceleration to a test vehicle. The EPs were produced by electrical stimulation of and recording from the motor pathway of experimental animals subjected to -Y (lateral impact) acceleration and animals subjected to -X (frontal impact) acceleration.

"Dr. Death" and the case for an ethical ban on psychiatric and psychological predictions of dangerousness in capital sentencing proceedings.

Psychiatric and psychological predictions of dangerousness are used in a number of American jurisdictions to convince a judge or jury that a convicted murderer should be sentenced to death. Empirical research has demonstrated, however, that psychiatric and psychological predictions of dangerousness generally are inaccurate. This Article describes the current use of such predictions in capital sentencing hearings and examines their status under existing professional codes of ethics.

Early somatosensory evoked potentials.

The early somatosensory evoked potential secondary to median nerve stimulation in the human had an onset latency of 9--12 msec when recorded from scalp electrodes at vertex-to-mastoid, vertex-to-inion or at the base of the skull. Similar latencies were observed from responses recorded over the cervical dorsal columns during neurologic surgery. A latency difference of 1.

Comparison of three techniques of lung lavage in patients with cystic fibrosis.

One hundred fifty-three lung lavage procedures were performed on 81 cystic fibrosis patients during the years 1963 to 1976. Local analgesia was used in 24 lavages done via a rigid bronchoscope and in a group of 73 lavages directed by a fiberoptic bronchoscope. No abnormalities in cardiac rate or rhythm were observed with the lavages directed by fiberoptic bronchoscope.