Comparison of Blood Loss with the Use of Intravenous and Intraarticular Tranexamic Acid Isolated Intraarticular in Primary Knee Arthroplasty.

 The objective of this work is to compare blood loss during primary knee arthroplasty with the use of intravenous and intraarticular (IV + IA) tranexamic acid intraarticular (IA) tranexamic acid alone.  This is a randomized, double-blind clinical trial. Patients with indication for primary total knee arthroplasty were recruited in a specialized clinic, where they were operated by the same surgeon, always using the same surgical technique.