Publications by authors named "Ewelina Lorenc"
Article Synopsis
- Peritoneal metastases from colorectal cancer are tough to treat, and while surgeries combined with hyperthermic intraperitoneal chemotherapy (HIPEC) can help, high recurrence rates and a lack of a standard chemotherapy choice remain challenges.
- This study explored the use of patient-derived organoids (PDO) as a model to enhance the effectiveness of HIPEC by testing various chemotherapy drugs on PDOs from twelve patients.
- Results showed significant variability in drug responses, highlighting that certain combinations, like mitomycin-c with cisplatin, were most effective, suggesting that PDOs can help tailor treatments and improve strategies for individual patients with colorectal cancer peritoneal metastases.
Atomic force microscopy (AFM) has become indispensable for studying biological and medical samples. More than two decades of experiments have revealed that cancer cells are softer than healthy cells (for measured cells cultured on stiff substrates). The softness or, more precisely, the larger deformability of cancer cells, primarily independent of cancer types, could be used as a sensitive marker of pathological changes.
View Article and Find Full Text PDFPeritoneal metastases (PM) are common routes of dissemination for colorectal cancer (CRC) and remain a lethal disease with a poor prognosis. The properties of the extracellular matrix (ECM) are important in cancer development; studying their changes is crucial to understand CRC-PM development. We studied the elastic properties of ECMs derived from human samples of normal and neoplastic PM by atomic force microscopy (AFM); results were correlated with patient clinical data and expression of ECM components related to metastatic spread.
View Article and Find Full Text PDFPeritoneal metastases (PM) from colorectal cancer (CRC) are associated with poor survival. The extracellular matrix (ECM) plays a fundamental role in modulating the homing of CRC metastases to the peritoneum. The mechanisms underlying the interactions between metastatic cells and the ECM, however, remain poorly understood, and the number of in vitro models available for the study of the peritoneal metastatic process is limited.
View Article and Find Full Text PDFArticle Synopsis
- Biosensors detect small physical and chemical changes in biological systems, crucial for understanding cellular processes like adhesion and migration.
- The extracellular matrix (ECM) significantly influences how cells react to external stimuli and affects their fate and development, showing important variations in health and disease.
- Atomic Force Microscopy (AFM) is a key technology that measures forces at the nanoscale, allowing for the characterization of mechanical properties of biological components, which can be correlated to microenvironment changes and health conditions.
Doxorubicin (DOX) therapy is limited by both cancer cells resistance and cardiotoxicity. DOX biotransformation to doxorubicinol (DOXol) by reductases enzymes (mainly by CBR1; carbonyl reductase 1) is a key process responsible for DOX adverse effects development. Thus, inhibition of CBR1 can increase the therapeutic effect of DOX.
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