The Potential Application of Resveratrol and Its Derivatives in Central Nervous System Tumors.

Resveratrol, a naturally occurring polyphenolic compound found in various plants, has been extensively studied for its broad spectrum of beneficial biological effects. These encompass its potent antioxidant properties, anti-inflammatory activities, anti-aging capabilities, cardioprotective functions, and neuroprotective potential. The diverse biological actions of resveratrol extend beyond these well-established properties.

Multifaced Nature of Yohimbine-A Promising Therapeutic Potential or a Risk?

A natural compound derived from the Pausinystalia yohimbe tree-yohimbine, has a rich history of use in traditional medicine and is currently being explored for its potential therapeutic applications. This indole alkaloid primarily acts as an antagonist of α2-adrenergic receptors. Initially recognized for its purported aphrodisiac properties, yohimbine has been investigated for a wide range of applications, including sports or the treatment of erectile dysfunction and metabolic disorders.

Dietary Fish Meal Replacement with and Larval Meals Improves the Growth Performance and Nutriphysiological Status of Ide () Juveniles.

The ide () is a native European species of rheophilic cyprinid fish whose wild population status is dependent on conservation efforts, particularly regular restocking. This study aimed to evaluate the effects of including insect meals as a component in the diet of ide juveniles on their growth performance, feed utilization, and nutriphysiological status. Four diets were formulated: three with insect meals, HI-with 20% meal, TM-with 20% meal, and ZM-with 20% meal, and the control group diet, CON-fish meal with no insect component.

Pain Management Strategies among Cancer Patients. Normalization of the CSQ (The Pain Coping Strategies Questionnaire) Form.

Introduction: Cancer is associated with chronic pain, which significantly reduces the quality of life. The level of pain depends on the dominant pain management strategy that the patient uses.

Objective: This study seeks to evaluate the application of the Pain Coping Strategies Questionnaire among cancer patients and develop norms allowing differentiation of patients with diagnosed cancer in terms of pain management strategies.

Modulation of Intestinal Histology by Probiotics, Prebiotics and Synbiotics Delivered In Ovo in Distinct Chicken Genotypes.

The aim of the study was to determine the effect of probiotics, prebiotics and synbiotics administered in ovo on selected morphological parameters of the small intestine (duodenum, jejunum, ileum) in broiler chickens (Ross 308) and native chickens (Green-legged Partridge, GP). On the 12th day of embryonic development (the incubation period), an aqueous solution of a suitable bioactive substance was supplied in ovo to the egg's air cell: probiotic- subsp. (PRO), prebiotic-GOS, galacto-oligosaccharides (PRE) or symbiotic-GOS + subsp.

Effects of a Trans-Galactooligosaccharide on Minerals Content of Common Carp (Cyprinus carpio L.) Tissues.

Common carp (Cyprinus carpio L.) is a dominant fish species in aquaculture, and as it is a stomachless species, absorption and digestion of nutrients take place in the intestine. The aim of the study was to evaluate the effects of a prebiotic on the content of selected minerals found in the meat, gills, and skeleton of common carp.

Effects of a Trans-Galactooligosaccharide on Biochemical Blood Parameters and Intestine Morphometric Parameters of Common Carp (Cyprinus carpio L.).

The aim of the study was to evaluate the effects of a trans-galactooligosaccharide prebiotic (GOS) on the growth performance, biochemical blood parameters, and intestine morphometric parameters of common carp. The 60-day-long experiment was performed on one-year-old fish with a mean body weight of 180 g (±5 g). Three diets were used: control diet 1 (C) with no microbiota affecting feed additives, diet 2 (B1) with 1% of prebiotic, and diet 3 (B2) with 2% of prebiotic, in four replications (tanks) per treatment and 25 fish per tank.

The role of postoperative radiotherapy in prostate cancer patients.

Aim Of The Study: The aim of the study was to evaluate the effectiveness of postoperative radiotherapy in prostate cancer patients with unfavorable prognostic factors.

Material And Methods: In the years 2002-2008, 121 consecutive prostate cancer patients underwent radical prostatectomy and postoperative radiotherapy. The median dose was 64 Gy (range: 60-72 Gy).

The side effects of hormonal therapy at the patients with prostate cancer.

Prostate cancer is one of most frequent malignant tumours at men. The androgen-deprivation therapy is the part of cancer treatment. It could be used both in the early stage of prostate cancer and in the bone metastates.

Acute pulmonary embolus in the course of cancer.

Risk of pulmonary embolism (PE) is relatively high in patients with advanced chronic diseases, particularly with malignancies. Most patients with cancer have blood coagulation test abnormalities indicative of up-regulation of the coagulation cascade, increased platelet activation and aggregation. Pulmonary thromboembolism is common in patients with any cancer and incidence is increased by surgery, chemotherapy, radiotherapy and disease progression.

Psoriasis exacerbation after hormonotherapy in prostate cancer patient-Case report.

Psoriasis, as the most common inflammatory skin disorder, affects about 2-3% of the world's population. Many non-dermatological conditions have been linked with psoriasis, including cardiovascular diseases, depression, inflammatory bowel disorders, and some cancers, i.e.

[The concentration of tissue--type plasminogen activator (t-PA) in extracts of breast cancer tissue].

Unlabelled: Degradation of the extracellular matrix metalloproteinases, which are activated mainly by the plasmin (the key enzyme of the fibrinolysis system), is the basis of the invasion of breast cancer cells. The tissue plasminogen activator (t-PA), a specific serine protease, is one of the plasmin activators. Shifting the balance between factors stimulating and inhibiting angiogenesis within the tumour microenvironment it influences negatively the progression of breast cancer.

Randomized clinical trial on 7-days-a-week postoperative radiotherapy for high-risk squamous cell head and neck cancer.

Purpose: To evaluate the normal tissue reactions and loco-regional control rates (LRC) in patients treated with 7-days-a-week postoperative continuous irradiation (p-CAIR) compared to conventionally fractionated 5-days-a-week postoperative radiotherapy (CF).

Materials/methods: Between 2001 and 2004, 279 patients with high-risk squamous cell cancer of the larynx (158 pts.) or cancer of the oral cavity/oropharynx (121 pts.

Radiotherapy in the prevention of heterotopic ossification after arthroplasty.

Heterotopic ossification (HO) is defined as the formation of mature lamellar bone in nonosseous tissues. HO is a common problem following total hip replacement (THR) and surgical repair of traumatic acetabular fracture (TAF). Without receiving any kind of prophylaxis the incidence of HO in patients with THR is about 30-80%.

Randomized clinical trial on continuous 7-days-a-week postoperative radiotherapy for high-risk squamous cell head-and-neck cancer: a report on acute normal tissue reactions.

Background And Purpose: To analyse acute mucosal reactions in patients treated with continuous accelerated postoperative irradiation (p-CAIR) compared to conventionally fractionated postoperative radiotherapy (p-CF).

Patients And Methods: The patients were randomly assigned to receive 63 Gy in 1.8 Gy fractions 7-days-a-week given over a period of 5 weeks (n=88), or 63 Gy in 1.