Publications by authors named "Ewa Tulodziecka"
Commun Biol
November 2022
Article Synopsis
- The druggability of proteins is essential for selecting effective drug targets, leading to the development of DrugnomeAI, a machine learning tool that predicts druggability for every protein-coding gene in the human exome.
- DrugnomeAI pulls data from 15 different sources, producing 324 features and achieving an impressive median AUC score of 0.97 based on known drug targets, with protein-protein interaction features being key predictors.
- The tool offers both general and specialized models based on disease type or drug therapy, revealing strong correlations with clinically relevant genes and providing a web application for users to explore druggability predictions.
