Publications by authors named "Ewa Tronczynska"
Article Synopsis
- * Genetic factors, particularly those within the major histocompatibility complex (MHC), play a significant role in MS risk, with studies revealing both a familial connection and numerous susceptibility loci through genome-wide association studies (GWAS).
- * A large collaborative GWAS identified additional risk loci and refined the understanding of specific genes like HLA-DRB1 and HLA-A, suggesting a strong immunological component in the development of MS, particularly involving T-helper cell differentiation.
We have performed the first systematic search for MS susceptibility genes completed in the Polish population. This screen was performed using 6000 microsatellite markers typed in pooled DNA from cases (n=200), controls (n=200) and trio families (n=129). Five associated markers are identified, one (D6S2444) from the HLA region and four are from novel regions not previously associated with MS, 2p16 (D2S2153), 3p13 (D3S3568), 7p22 (D7S2521) and 15q26 (D15S649).
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