Validated allergen exposure chamber is plausible tool for the assessment of house dust mite-triggered allergic rhinitis.

Background: Allergen exposure chamber (AEC) is a clinical facility that allows exposure to allergenic airborne particles in controlled environment. Although AECs offer stable levels of airborne allergens, the validation of symptoms and other endpoints induced by allergen challenge is key for their recommendation as a plausible tool for the assessment of patients, especially in clinical research. This study aimed to demonstrate the reproducibility of defined clinical endpoints after AEC house dust mite (HDM) challenge under optimal conditions in patients with allergic rhinitis (AR).

Apoptotic regulators: P53 and survivin expression in non-small cell lung cancer.

Background: Survivin and p53 are proteins that take part in cell cycle and apoptosis regulation. The biological function of survivin is essential for its oncogenic potential. The p53 protein is known to be a guardian of the genome and alterations in its structure enhance resistance to apoptosis.

[Evaluation of expression and correlation between P53, BCL-2 and BAX proteins in ovarian neoplasms].

Objectives: Interactions between BCL-2 and other proteins regulating programmed cells death in ovarian carcinomas are poorly understood.

Design: The evaluation of expression of P53, BCL-2 and BAX proteins in ovarian carcinomas. The associations between oncoproteins studied and the histological structure, grade of differentiation and stage of disease were also analysed.