Publications by authors named "Ewa Proniewvska-Skretek"
Klin Oczna
September 2005
Article Synopsis
- The genetic mechanisms behind ocular melanoma are not well understood compared to skin melanoma, with research suggesting that it may arise from genetic changes in normal melanocytes.
- Genetic alterations linked to choroidal melanoma include deletions and amplifications on several chromosomes (3, 6, 8, 9, 11, and 18) along with point mutations that lead to monosomy or loss of heterozygosity.
- These genetic changes can produce faulty proteins, such as p16 and p14, which normally help suppress cancer development; defects in these proteins may contribute to the formation of melanoma.
