The Anti-Serotonin Effect of Parthenolide Derivatives and Standardised Extract from the Leaves of .

The presence of dominant active compounds in standardised methanol extract from the leaves of () was examined using HPLC with a diode-array detector. The extract and three dominant parthenolide derivatives were tested with Serotonin Research ELISA for their ability to inhibit the serotonin release from platelets. The antiserotonin effect of the extract was compared with that of parthenolide, a compound with proven antiserotonin and antimigraine effects.