Publications by authors named "Ewa Hainaut"
Article Synopsis
- Sézary syndrome is a rare and deadly skin cancer, and this study looked into the survival rates and factors affecting outcomes, particularly focusing on the treatment mogamulizumab.
- *The research analyzed data from 339 patients diagnosed between 2000 and 2020 across Europe, highlighting that age over 80 and large-cell transformation worsened survival rates.
- *Results indicated that patients treated with mogamulizumab had significantly lower mortality rates, suggesting it is an effective treatment option for Sézary syndrome.
Acne in adult females is triggered mainly by hormones. Doxycycline is a reference treatment in acne. Spironolactone targets the androgen receptor of sebaceous glands and is prescribed off-label for female adult acne.
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- Chronic granulomatous disease (CGD) is an inherited immunodeficiency caused by faulty NADPH in leukocytes, leading to frequent infections and inflammation.
- The condition is mainly due to mutations in the CYBB gene, predominantly affecting males, but females can also show symptoms based on their X-inactivation patterns.
- A case study highlights a 67-year-old asymptomatic female carrier diagnosed with CGD after developing a rare fungal skin infection, revealing the importance of monitoring carriers for late onset diseases.
Article Synopsis
- Subcorneal pustular dermatosis (SPD), also known as Sneddon-Wilkinson disease, is a skin condition with unclear treatment guidelines, but anti-TNFα therapies show promise in resistant cases.
- In two cases, elderly women with SPD related to monoclonal IgA gammopathy experienced significant improvement with anti-TNFα treatments, specifically infliximab and adalimumab, after previous therapies failed.
- Relapses occurred in both patients, but switching medications or adjusting dosage intervals successfully restored treatment effectiveness, suggesting a need for individualized treatment approaches in SPD.
This retrospective observational study aimed to determine the effectiveness, safety and patterns of the use of nivolumab in patients with advanced melanoma in real-world clinical practice in France using data from a Temporary Authorization for Use Program (ATU). Data were collected from patients with unresectable or metastatic melanoma enrolled in a French national database (Réseau pour la Recherche et l'Investigation Clinique sur le Mélanome: Ric-Mel) and treated with nivolumab during the ATU program (12 September 2014 to 31 August 2015). The primary objectives of the study were to evaluate the effect of patient characteristics on clinical response and overall survival (OS).
View Article and Find Full Text PDFBackground: Schnitzler syndrome (SchS) is a rare autoinflammatory disease characterized by urticarial exanthema, bone and joint alterations, fever and monoclonal IgM gammopathy. Overactivation of the interleukin(IL)-1 system is reported, even though the exact pathophysiological pathways remain unknown.
Objective: To determine v cytokine profiles of Peripheral Blood Mononuclear Cells (PBMCs) from SchS patients prior to treatment and after initiation of anti-IL-1 therapy (anakinra).
Background: Acne vulgaris has increased in women over the past 10 years; it currently affects 20-30% of women. The physiopathology of adult female acne is distinguished from that of teenagers essentially by two factors: hormonal and inflammatory. On a therapeutic plan, the four types of systemic treatment approved for female acne include cyclines (leading to bacterial resistance); zinc salts (less effective than cyclines); and antiandrogens (risks of phlebitis).
View Article and Find Full Text PDFPhotodistributed sarcoidosis with ophthalmic, arterial and pulmonary symptoms.
Photodermatol Photoimmunol Photomed
March 2020
Background: Extra-mammary Paget's disease is a rare form of intraepithelial adenocarcinoma with a variable pattern of invasion, sometimes associated with distant malignancy. Vulvar Paget's disease (VPD) represents 1% of all vulvar cancers. Standard treatment is surgical excision, however, the recurrence rate is high and surgery leads to anatomical, functional, and sexual morbidity.
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