Publications by authors named "Ew-Jun Chen"
Tumour-induced osteomalacia is a rare paraneoplastic syndrome that manifests as chronic hypophosphataemia, non-specific bone pain and muscle weakness. It is generally caused by phosphaturic mesenchymal tumour (PMT), which is uncommonly associated with synchronous tumours. However, diagnosis is often delayed for several years due to the rarity, indolent growing nature and non-specific symptoms of the disease, often resulting in an overlook by clinicians during assessments.
View Article and Find Full Text PDFRecent case reports and series have demonstrated the usefulness of Ga/F-PSMA PET/CT in restaging recurrent renal cancer after nephrectomy. We presented a case of a patient with renal mass who had undergone both F-FDG and Ga-PSMA PET/CT for diagnosis and staging. Concordant tracer uptake in the primary tumor and metastatic lesions was demonstrated by both radiotracers.
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- - LRRK2IN1 is a powerful inhibitor of LRRK2, a target for Parkinson's disease treatment, with an IC50 of 7.9 nM; two analogues (1 and 2) were created showing similar activity but with improved bioavailability (1: IC50 = 72 nM; 2: IC50 = 51 nM).
- - Analogue 1 effectively inhibited IL-6 secretion from LPS-stimulated human microglia at an EC50 of 4.26 μM, exhibiting anti-neuroinflammatory properties.
- - A library of truncated analogues was developed, which although they lacked LRRK2 inhibition, demonstrated anti-neuroin