Background: Burn injury progression in the secondary zone of ischemia is common leading to delayed healing and increased scarring. We hypothesized that a topical surfactant, would reduce burn injury progression in a validated rat comb burn model compared with topical antibiotic ointment.
Methods: We created 40 comb burns on 20 rats which were randomized to daily topical application of the surfactant or a triple antibiotic ointment.