Publications by authors named "Evren C Eroglu"
Fetal growth restriction (FGR) is accompanied by early activation of hepatic glucose production (HGP), a hallmark of type 2 diabetes (T2D). Here, we used fetal hepatic catheterization to directly measure HGP and substrate flux in a sheep FGR model. We hypothesized that FGR fetuses would have increased hepatic lactate and amino acid uptake to support increased HGP.
View Article and Find Full Text PDFGC-MS based metabolite fingerprinting of serous ovarian carcinoma and benign ovarian tumor.
Eur J Mass Spectrom (Chichester)
February 2022
Article Synopsis
- * Seven specific metabolites showed significant differences between ovarian cancer (OC) and benign tumor (BT) patients, with high model sensitivity (90.72% for OC vs. BT) and specificity (82.09%), indicating strong predictive capability.
- * Pathway analyses highlighted important biological processes related to the metabolites, including glutathione metabolism and aminoacyl-tRNA biosynthesis, further developing the understanding of ovarian cancer mechanisms and potential diagnostic markers.
Article Synopsis
- The study investigates ovarian cancer patients’ responses to platinum-based treatment, focusing on differentiating those who are platinum-resistant from those who are sensitive using metabolomic analysis of urine and serum samples.
- By examining metabolites through GC-MS and applying multivariate analysis, researchers identified specific biomarkers associated with platinum resistance, such as 3,4-dihydroxyphenylacetic acid and L-arginine.
- The findings reveal significant metabolic pathways involved in these differences, highlighting the relevance of tyrosine metabolism and nitrogen metabolic pathways, which could guide alternative treatment strategies for resistant patients.
There is a large potential in Europe for valorization in the vegetable food supply chain. For example, there is occasionally overproduction of tomatoes for fresh consumption, and a fraction of the production is unsuited for fresh consumption sale (unacceptable color, shape, maturity, lesions, etc.).
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