Publications by authors named "Eviania Likos"
Metabolic reprogramming enables cancer cells to proliferate and produce tumor biomass under a nutrient-deficient microenvironment and the stress of metabolic waste. A cancer cell adeptly undergoes a variety of adaptations in metabolic pathways and differential expression of metabolic enzyme genes. Metabolic adaptation is mainly determined by the physiological demands of the cancer cell of origin and the host tissue.
View Article and Find Full Text PDFThe Androgen Receptor (AR), transcriptionally activated by its ligands, testosterone and dihydrotestosterone (DHT), is widely expressed in cells and tissues, influencing normal biology and disease states. The protein product of the AR gene is involved in the regulation of numerous biological functions, including the development and maintenance of the normal prostate gland and of the cardiovascular, musculoskeletal and immune systems. Androgen signalling, mediated by AR protein, plays a crucial role in the development of prostate cancer (PCa), and is presumed to be involved in other cancers including those of the breast, bladder, liver and kidney.
View Article and Find Full Text PDFArticle Synopsis
- Disruption in lipid and cholesterol metabolism can lead to metabolic and cardiovascular diseases, regulated primarily through two major transcription pathways: SREBP for cholesterol synthesis and LXR/RXR for cholesterol transport.
- Small non-coding microRNAs (miRNAs) play a crucial role in the posttranscriptional control of genes involved in cholesterol metabolism, impacting both the mRNA levels and translation of vital proteins.
- This review highlights the regulatory functions of miRNAs on cholesterol and lipid metabolism, their effects on key molecules, and the potential for using miRNAs in enhancing small molecule therapies for related diseases.