Publications by authors named "Evgina Svetlana"
Article Synopsis
- The study established reference intervals (RIs) and analyzed biological variability (BV) to facilitate the introduction of the thrombin generation test (TGT) into clinical practice.
- It involved testing platelet-poor plasma (PPP), platelet-rich plasma (PRP), and microparticle-mediated TGT in healthy participants, utilizing nested ANOVA for BV evaluation across multiple weeks.
- Results indicated varying degrees of individual and analytical variation for TGT parameters, leading to recommended RIs for evaluating thrombin generation based on PPP and PRP, with important implications for clinical monitoring.
Objectives: A multicenter study was organized to explore sources of variation (SVs) of reference values (RVs) for 22 major immunochemistry analytes and to determine reference intervals (RIs) for the Russian population.
Methods: According to IFCC Committee on Reference Intervals and Decision Limits (C-RIDL) protocol, 758 healthy volunteers were recruited in St. Petersburg, Moscow, and Yekaterinburg.
Objectives: Because reference intervals (RIs) for biochemistry analytes matched to the Russian population are not well defined, we joined the global study on reference values (RVs) coordinated by the IFCC Committee on Reference Intervals and Decision Limits (C-RIDL).
Methods: According to the C-RIDL harmonized protocol, 793 healthy volunteers were recruited in Saint-Petersburg, Moscow, and Yekaterinburg. Serum samples were tested for 34 biochemistry analytes.
Article Synopsis
- The IFCC Committee conducted a global study to create harmonized reference intervals (RIs) for medical testing, examining variations in reference values (RVs) across different countries.
- The study involved 12 countries and over 13,000 healthy adults, measuring 50 different analytes to determine RIs through multiple statistical methods.
- Results revealed significant differences in RVs among countries, particularly influenced by factors like nutritional status and BMI, suggesting a need for further validation to ensure accurate medical assessments.