Publications by authors named "Evgeny V Kryukov"
Objective: S-Adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) are indicators of global transmethylation and may play an important role as markers of severity of COVID-19.
Methods: The levels of plasma SAM and SAH were determined in patients admitted with COVID-19 ( = 56, mean age = 61). Lung injury was identified by computed tomography (CT) in accordance with the CT0-4 classification.
Article Synopsis
- Aminothiols, like glutathione (GSH) and cysteinylglycine (CG), might be important in understanding the severity of COVID-19, but their exact role hasn't been fully explored yet.
- A study of 59 COVID-19 patients found that lower total glutathione (tGSH) levels were linked to a higher risk of severe illness and more lung damage, while levels of reduced cysteinylglycine (rCG) were also associated with lung injury.
- The findings suggest that tGSH and rCG could serve as useful indicators for assessing COVID-19 severity, highlighting the need to potentially adjust glutathione levels as part of treatment.
Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia.
Lancet
September 2020
Background: We developed a heterologous COVID-19 vaccine consisting of two components, a recombinant adenovirus type 26 (rAd26) vector and a recombinant adenovirus type 5 (rAd5) vector, both carrying the gene for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein (rAd26-S and rAd5-S). We aimed to assess the safety and immunogenicity of two formulations (frozen and lyophilised) of this vaccine.
Methods: We did two open, non-randomised phase 1/2 studies at two hospitals in Russia.
Light propagation in uniaxial chiral media with large pitch is studied. In these systems there are forbidden zones for extraordinary beams, which lead to effective reflection on zone boundaries and to wave damping inside the forbidden zone. We analyze the vicinities of the turning points and the transition of an extraordinary wave through the forbidden zone.
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