Morphologic characteristics of Chernobyl-related childhood papillary thyroid carcinomas are independent of radiation exposure but vary with iodine intake.

Background: The Chernobyl accident caused an unprecedented increase in papillary thyroid carcinoma (PTC) incidence with a surprisingly short latency and unusual morphology. We have investigated whether unexpected features of the PTC incidence after Chernobyl were radiation specific or influenced by iodine deficiency.

Methods: PTCs from children from Belarus, Ukraine, and the Russian Federation exposed to fallout from Chernobyl were compared with PTCs from children not exposed to radiation from the same countries, from England and Wales (E&W) and from Japan.

Quantitative changes in thyroid lymphoid cells as a marker of malignancy.

Objective: To investigate the possibility of using morphometric changes in lymphoid cells in thyroid tissue as a marker of malignant tumors.

Study Design: Morphometry of biopsy material was performed with a semiautomated, computerized image analyzer.

Results: Nine features were selected.

Morphometric analysis of the degree of aggregation of follicular cells in the diagnosis of malignant thyroid tumors.

Objective: To develop a system of decision criteria based on a set of features of the degree of thyrocyte aggregation with assessment of their weighting coefficient in the diagnosis of malignant and benign thyroid pathology.

Study Design: Autopsy, operative and aspiration biopsy material were the object of the study. Light microscopic morphometry was performed with semiautomated computer analysis of images.