Publications by authors named "Evgeny Melnikov"
A novel HPLC-ESI-MS/MS method for simultaneous gonadotropin-releasing hormone (GnRH) analogs and somatostatin analog quantitation was developed and validated. The developed method was successfully applied to pharmacokinetic studies. The sample preparation process included solid-phase extraction (SPE).
View Article and Find Full Text PDFThe Effect of Coenzyme Q10 as a Part of Standard Therapy on Plasma Concentrations of Ubiquinol, Ubiquinone, Total CoQ10 and its Redox State in Patients with Ischemic Heart Disease.
Curr Drug Metab
January 2022
Background: Despite CoQ10 being a powerful antioxidant and its redox state that may characterize the body's antioxidant system, the latter remains unstudied in patients with cardiovascular diseases.
Objective: This prospective case-control study aimed to investigate the concentrations of ubiquinol, ubiquinone, total CoQ10 and its redox state in patients with ischemic heart disease (IHD) and arterial hypertension (AH) during standard therapy and with the additional prescription of CoQ10.
Methods: The study included 54 healthy individuals and 26 patients, who were divided into a control group receiving standard therapy and a test group receiving CoQ10 in addition to standard therapy.
Article Synopsis
- Coenzyme Q10 (CoQ10) levels are significantly lower in patients with cardiovascular diseases (CVDs) compared to healthy individuals.
- Administration of atorvastatin leads to a further decrease in CoQ10 levels, while amlodipine and ethoxidol are linked to increases in CoQ10 levels.
- The study recommends adjusting therapy for patients to maintain appropriate CoQ10 levels and prevent negative health effects associated with its deficiency.