Reduced number and function of CD4+CD25highFoxP3+ regulatory T cells in patients with systemic lupus erythematosus.

CD4+CD25+ regulatory T cells (Tregs) play an important role in maintaining tolerance to self-antigens controlling occurrence of autoimmune diseases. Recently, it has been shown that the transcription factor forkhead box P3 (FoxP3) is specifically expressed on CD4+CD25+ T cells. FoxP3 has been described as the master control gene for the development and function of Tregs.

Musculoskeletal disorders in Russia at the end of the 20th century.

The situation with musculoskeletal disorders in Russia is described. Developments include markedly increased musculoskeletal morbidity in both adults and children. The burden of disease has also increased both from a medical and socioeconomic standpoint, as the numbers of disabled continue to grow.