Publications by authors named "Evgenia V Tsyrlina"
Article Synopsis
- The coexistence of type 2 diabetes with breast cancer can negatively impact survival rates, potentially due to changes in tumor hormone sensitivity.
- Previous studies have noted alterations in breast tumor receptor status among diabetic patients, yet often overlook the type of diabetes treatment received.
- This analysis of receptor status in 90 postmenopausal women indicated that those treated with metformin had a higher occurrence of progesterone receptor-positive tumors compared to those treated only with sulfonylureas or insulin, highlighting the need to consider diabetes treatment types when examining cancer outcomes.
The abundance of fat tissue surrounding normal and malignant epithelial mammary cells raises the questions whether such "adipose milieu" is important in the local proinflammatory/genotoxic shift, which apparently promotes tumor development and worsens prognosis, and what conditions stimulate this shift, or "adipogenotoxicosis." We studied 95 mammary fat samples from 70 postmenopausal and 25 premenopausal breast cancer (BC) patients at a distance of 1.5-2.
View Article and Find Full Text PDFEstrogens and glucose are characterized by a myriad of functions that can be reduced to a small number of principal actions. In aging there is a simultaneous increase in the prevalence of diseases connected with estrogen deficiency as well as with estrogenic excess and associated with the phenomenon of the switching of estrogen effects (PSEE). Estrogens possess hormonal and genotoxic properties.
View Article and Find Full Text PDF