The effect of naltrexone on body fat mass in olanzapine-treated schizophrenic or schizoaffective patients: a randomized double-blind placebo-controlled pilot study.

Olanzapine (OLZ), a commonly prescribed second generation antipsychotic drug, is associated with obesity and metabolic syndrome and may contribute to increased cardiovascular morbidity and mortality. Opioidergic neurotransmission may be implicated in the development of these metabolic disturbances. The objective of this study was to assess the effects of opioid blockade on OLZ-treated patients' metabolic status.

Neurological soft signs in individuals with pathological gambling.

Increased neurological soft signs (NSSs) have been found in a number of neuropsychiatric syndromes, including chemical addiction. The present study examined NSSs related to perceptual-motor and visuospatial processing in a behavioral addiction viz., pathological gambling (PG).

Yohimbine-induced amygdala activation in pathological gamblers: a pilot study.

Rationale And Objectives: There is evidence that drug addiction is associated with increased physiological and psychological responses to stress. In this pilot functional magnetic resonance imaging (fMRI) study we assessed whether a prototype behavioral addiction, pathological gambling (PG), is likewise associated with an enhanced response to stress.

Methods: We induced stress by injecting yohimbine (0.

Gender differences in psychosocial stress and in its relationship to gambling urges in individuals with pathological gambling.

Gender differences in the impact of psychosocial stress and in negative affective states were assessed in a group of pathological gamblers matched by demographic characteristics and by severity of gambling. Women displayed higher impact scores on the Daily Stress Inventory. Other stress measures, obtained with the Profile of Mood States (POMS), were also significantly elevated in the women group.

Psychosocial stress and its relationship to gambling urges in individuals with pathological gambling.

We sought to explore a potential link between psychosocial stress exposure and pathological gambling (PG). Patients with PG displayed significantly higher scores on the daily stress inventory (DSI) than did healthy subjects. PG patients also displayed other heightened measures of stress, including the profile of mood states, the Spielberger state-trait anxiety inventory, the Hamilton rating scale for depression and the Beck depression inventory.