Angular Phenozaxine Ethers as Potent Multi-microbial Targets Inhibitors: Design, Synthesis, and Studies.

The reaction of diaza-5H-benzo[a]phenoxazin-5-one and 5H-benzo[a]phenoxazin-5-one with various phenols catalyzed by Pd/t-BuXPhos/KPO system gave previously unknown ether derivatives ( and ) in good yields. UV-visible, FTIR, and H NMR data were used to confirm structures of the synthesized compounds. The parent compounds and the derivatives were screened for their drug-likeness and binding affinities to the microbial targets through molecular docking.