Publications by authors named "Evelyn Mendes Fernandes"
Article Synopsis
- - The study investigates the impact of LED therapy on mdx mice, a model for Duchenne muscular dystrophy (DMD), which shows worsened symptoms with chronic exercise, making it suitable for testing treatments.
- - Mdx mice underwent treadmill training coupled with LED treatment, leading to improved behaviors and muscle function, along with reduced muscle damage and inflammation.
- - Notably, LED therapy shifted macrophage behavior towards better tissue repair and highlighted the connection between calcium, oxidative stress, and inflammation in potentially treating dystrophinopathies.
Purpose: Considering the difficulties and challenges in Duchenne muscular dystrophy (DMD) treatment, such as the adverse effects of glucocorticoids, which are the main medical prescription used by dystrophic patients, new treatment concepts for dystrophic therapy are very necessary. Thus, in this study, we explore the effects of photobiomodulation (PBM; a non-invasive therapy) and Idebenone (IDE) treatment (a potent antioxidant), applied alone or in association, in dystrophic muscle cells and the quadriceps muscle, with special focus on autophagy and regenerative pathways.
Methods: For the in vitro studies, the dystrophic primary muscle cells received 0.