Longitudinal analysis of genotype with the logical memory delayed recall score in Alzheimer's disease.

No study has focussed on the longitudinal effect of genotype on the logical memory delayed recall total (LDELTOTAL) score in late-onset Alzheimer's disease (AD). The LDELTOTAL scores were collected at baseline, 12, 24, 36 and 48 months from 382 participants with AD, 503 with cognitive normal (CN), 1293 with mild cognitive impairment (MCI) in the Alzheimer's Disease Neuroimaging Initiative (ADNI). A linear mixed model (LMM) was used to investigate the effect of on the longitudinal changes in the LDELTOTAL scores adjusted for age, gender, education and baseline Mini Mental State Examination score.