Publications by authors named "Evelyn De Tavernier"
Article Synopsis
- The study focuses on how antibodies are characterized using B cells and highlights the challenges with analyzing plasma cells due to their lack of surface B cell receptors (BCRs).
- Researchers explored the antibody repertoires from bone marrow and spleen in a mouse model, overcoming technical limitations to include plasma cells in their analysis.
- Results showed that spleen B cells produced higher affinity antibodies than bone marrow plasma cells, with evidence of shared origins for some antibody clones between the two lymphoid tissues.
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases affecting primarily the joints. Despite successful therapies including antibodies against tumor necrosis factor (TNF) and interleukin-6 (IL-6) receptor, only 20 to 30% of patients experience remission. We studied whether inhibiting both TNF and IL-6 would result in improved efficacy.
View Article and Find Full Text PDFImproving potencies through concomitant blockage of multiple epitopes and avid binding by fusing multiple (different) monovalent Nanobody building blocks via linker sequences into one multivalent polypeptide chain is an elegant alternative to affinity maturation. We explored a large and random formatting library of bivalent (combinations of two identical) and biparatopic (combinations of two different) Nanobodies for functional blockade of Pseudomonas aeruginosa PcrV. PcrV is an essential part of the P.
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