Publications by authors named "Evelyn Cristina da Silva Santos"
Article Synopsis
- The study investigates anxiety-like behaviors in two female mouse strains (Swiss and C57BL/6) and their responses to stress, revealing different baseline anxiety levels and reactions to stressful situations.
- C57BL/6 mice showed lower anxiety levels compared to Swiss mice and were more affected by stress, developing an anhedonic state with reduced preference for sucrose solutions.
- The findings suggest that the behavioral responses are linked to distinct levels of corticosterone and differences in glucocorticoid receptor (GR) expression in the hippocampus, indicating a dysregulation in stress response systems in C57BL/6 mice.
Article Synopsis
- * The study investigates the effects of an enriched environment (EE) on fear extinction and how it relates to NPY-Y1 receptor modulation, using an experimental PTSD approach with rats.
- * Results show that rats in an EE context experienced improved fear extinction, which was hindered by blocking Y1 receptors, indicating that NPY signaling in the hippocampus is essential for better context recognition and reduced fear generalization.
GABA-A receptor modulators alter emotionality and hippocampal theta rhythm in an animal model of long-lasting anxiety.
Alexandre Ademar Hoeller Marcelo Duzzioni Filipe Silveira Duarte Leandro Rinaldi Leme Ana Paula Ramos Costa Evelyn Cristina da Silva Santos Alessandra Antunes dos Santos
Brain Res
September 2013
Article Synopsis
- The cholinergic system plays a role in regulating emotions, with the muscarinic receptor agonist pilocarpine inducing anxiety in rats over extended periods (24 hours to 3 months).
- Rats treated with pilocarpine exhibited changes in behavior in an elevated plus-maze test, where anxiolytic treatment with diazepam blocked anxiety responses, while anxiogenic treatment did not affect them.
- Electroencephalographic recordings showed increased theta activity in the hippocampus, illustrating long-term electrophysiological changes that suggest the muscarinic system could be a target for anxiety disorder treatments.
A proposal for refining the forced swim test in Swiss mice.
Ana Paula Ramos Costa Cintia Vieira Lauren O L Bohner Cristiane Felisbino Silva Evelyn Cristina da Silva Santos
Prog Neuropsychopharmacol Biol Psychiatry
August 2013
The forced swim test (FST) is a preclinical test to the screening of antidepressants based on rats or mice behaviours, which is also sensitive to stimulants of motor activity. This work standardised and validated a method to register the active and passive behaviours of Swiss mice during the FST in order to strength the specificity of the test. Adult male Swiss mice were subjected to the FST for 6 min without any treatment or after intraperitoneal injection of saline (0.
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