Context-dependent effects of rimonabant on ethanol-induced conditioned place preference in female mice.

Background: The CB1 receptor antagonist rimonabant has been previously found to prevent behavioral effects of drugs of abuse in a context-dependent manner, suggesting an important role of endocannabinoid signaling in drug-induced environmental conditioning. The aim of the present study was to evaluate the effects of rimonabant on ethanol-induced conditioned place preference (CPP) in female mice.

Methods: Animals were conditioned with saline or ethanol (1.