Analysis of skin and corneal fiber electrodes for electroretinogram assessments in patients with major depressive disorder.

Background: Electroretinograms (ERG) are usually recorded with non-invasive corneal electrodes, requiring direct contact with the ocular surface. However, corneal electrode application is not tolerated by some individuals. The advent of handheld ERG devices has facilitated the use of skin electrodes for ERG measurements.

Effect of eccentric fixation on the steady-state pattern electroretinogram.

Purpose: The steady-state pattern electroretinogram (ssPERG) is used to assess retinal ganglion cell function in a variety of research contexts and diagnostic applications. In certain groups of patients or study participants, stable central fixation of the stimulus is not guaranteed. The present study aimed at assessing the effects of misfixation on the ssPERG response to checkerboard reversal stimuli.

Retinal Thinning in Adults with Autism Spectrum Disorder.

Since the retina shares its embryological origin with the central nervous system, optical coherence tomography (OCT), an imaging technique frequently employed in ophthalmology to analyze the macula and intraretinal layer thicknesses and volumes, has recently become increasingly important in psychiatric research. We examined 34 autistic and 31 neurotypical adults (NT) using OCT. Autistic adults had reduced overall macular and outer nuclear layer (ONL) thickness and volume compared to NT.

Electroretinography in adults with high-functioning autism spectrum disorder.

The electroretinogram (ERG) allows the investigation of retinal signaling pathways and has increasingly been applied in individuals with mental disorders in search for potential biomarkers of neurodevelopmental disorders. Preceding ERG examinations in individuals with autism spectrum disorders (ASD) showed inconsistent results, which might be due to the small number of participants, heterogeneity of the ASD population, differences in age ranges, and stimulation methods. The aim of this study was to investigate functional retinal responses in adults with ASD by means of the light-adapted (photopic) ERG.

Structural and functional retinal alterations in patients with paranoid schizophrenia.

Ophthalmological methods have increasingly raised the interest of neuropsychiatric specialists. While the integrity of the retinal cell functions can be evaluated with the electroretinogram (ERG), optical coherence tomography (OCT) allows a structural investigation of retinal layer thicknesses. Previous studies indicate possible functional and structural retinal alterations in patients with schizophrenia.

Replication of Reduced Pattern Electroretinogram Amplitudes in Depression With Improved Recording Parameters.

The retina has gained increasing attention in non-ophthalmological research in recent years. The pattern electroretinogram (PERG), a method to evaluate retinal ganglion cell function, has been used to identify objective correlates of the essentially subjective state of depression. A reduction in the PERG contrast gain was demonstrated in patients with depression compared to healthy controls with normalization after remission.

Attentional Interactions Between Vision and Hearing in Event-Related Responses to Crossmodal and Conjunct Oddballs.

Are alternation and co-occurrence of stimuli of different sensory modalities conspicuous? In a novel audio-visual oddball paradigm, the P300 was used as an index of the allocation of attention to investigate stimulus- and task-related interactions between modalities. Specifically, we assessed effects of modality alternation and the salience of conjunct oddball stimuli that were defined by the co-occurrence of both modalities. We presented (a) crossmodal audio-visual oddball sequences, where both oddballs and standards were unimodal, but of a different modality (i.