Diagnostic Significance of Cytokeratin 20 and p53 as Adjunct Immunocytological Markers in Urine Cytology to Detect Urothelial Carcinomas: A Systematic Review Study.

The progression and recurrence of urothelial carcinoma (UC) are correlated with carcinoma and urothelial dysplasia. It is frequently challenging to distinguish dysplasia and carcinoma from reactive atypia only based on histological characteristics. In daily practices, 2 of the adjunct immunohistochemistry markers (cytokeratin 20 (CK20) and p53) are used in addition to the histology to diagnose carcinoma .