Chronic hernia repair in a rat model using small intestinal submucosa.

BACKGROUND. Small intestinal submucosa (SIS) body wall defect repair in preclinical studies results in host tissue that resembles original host tissue histologically and has adequate strength to maintain repair integrity. However, these studies have been performed using acute hernia models that may not represent healing in a naturally occurring hernia.

Tensile strength comparison of small intestinal submucosa body wall repair.

Background: Porcine small intestinal submucosa (SIS) has been studied for body wall repair. However, the best method to implant the biological material has not been investigated. The objective of this study was to compare tensile strengths achieved after healing when SIS was placed using three implant techniques (onlay, inlay, underlay) in a porcine model of abdominal wall defect.

Morphologic study of three collagen materials for body wall repair.

Background: The search for ideal prostheses for body wall repair continues. Synthetic materials such as polypropylene mesh (PPM) are associated with healing complications. A porcine-derived collagen-based material (CBM), small intestinal submucosa (SIS), has been studied for body wall repair.

Effect of topical administration of 1% morphine sulfate solution on signs of pain and corneal wound healing in dogs.

Objective: To evaluate the effect of topical application of a 1% morphine sulfate solution (MSS) on signs of pain and wound healing in dogs with corneal ulcers and examine normal corneas immunohistochemically for the presence of mu and delta opioid receptors.

Animals: 12 dogs.

Procedure: A 7-mm superficial corneal ulcer was surgically created in the right eye (OD) of 10 dogs, after which gentamicin solution and 1% MSS (n = 6) or saline solution (4) was administered topically OD 3 times daily.