Publications by authors named "Eveline den Biezen"
Clin Cancer Res
November 2023
Article Synopsis
- The study investigates the reasons why not all men with metastatic castration-resistant prostate cancer (mCRPC) respond to androgen receptor axis inhibitors (ARPI) like enzalutamide and abiraterone acetate.
- Researchers conducted whole-exome and RNA sequencing to identify genetic factors related to both primary and acquired resistance in 59 mCRPC patients, along with biopsies from 18 patients who exhibited resistance.
- Findings revealed no strong single-gene variations linked to initial resistance, but a combination of low androgen receptor activity and certain pathway alterations were associated with primary resistance, while acquired resistance was tied to subclonal evolution and changes in AR-related genes.
Cancers (Basel)
March 2021
Article Synopsis
- Targeted therapy focuses on blocking specific pathways that drive tumor growth, traditionally relying on analysis from a single primary tumor biopsy.*
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- Research shows that there can be significant variability in the functional activity of these signaling pathways within a primary tumor and its metastases, which could affect treatment effectiveness.*
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- While intra-tumor variation shows a positive correlation in pathway activity, this correlation diminishes when comparing primary tumors to metastases, suggesting that analyzing metastatic tumors is crucial for effective treatment predictions.*
