Publications by authors named "Eveline W C M van Dam"
Article Synopsis
- - The study examines the long-term cardiac health of adult survivors of pediatric differentiated thyroid cancer (DTC), finding that 20% exhibited early signs of heart dysfunction after initial treatment.
- - A follow-up over five years revealed that the ability of the heart to relax (measured by diastolic function) significantly decreased, while overall heart function (ejection fraction) remained stable in survivors.
- - Factors such as increasing age and higher body mass index (BMI) were linked to deterioration in heart function, suggesting the need for ongoing monitoring of these patients' cardiac health.
Objective: This study assessed the health-related quality of life (HRQoL) in patients undergoing 2-[18F]fluoro-2-deoxy-D-glucose (FDG)-PET/CT for an indeterminate (Bethesda III/IV) thyroid nodule. FDG-PET/CT accurately rules out malignancy and prevents 40% of futile diagnostic surgeries in these nodules.
Design: Secondary analyses of HRQoL data from a randomised controlled multicentre trial (NCT02208544) in 126 patients from 15 hospitals in the Netherlands were done.
Purpose: To assess the impact of an [F]FDG-PET/CT-driven diagnostic workup to rule out malignancy, avoid futile diagnostic surgeries, and improve patient outcomes in thyroid nodules with indeterminate cytology.
Methods: In this double-blinded, randomised controlled multicentre trial, 132 adult euthyroid patients with scheduled diagnostic surgery for a Bethesda III or IV thyroid nodule underwent [F]FDG-PET/CT and were randomised to an [F]FDG-PET/CT-driven or diagnostic surgery group. In the [F]FDG-PET/CT-driven group, management was based on the [F]FDG-PET/CT result: when the index nodule was visually [F]FDG-positive, diagnostic surgery was advised; when [F]FDG-negative, active surveillance was recommended.
Article Synopsis
- - The study examines bone mineral density (BMD) in pediatric survivors of differentiated thyroid carcinoma (DTC) who have undergone thyrotropin-suppressive therapy, focusing on the potential long-term effects of subclinical hyperthyroidism and permanent hypoparathyroidism.
- - Out of 65 participants, 29% exhibited subclinical hyperthyroidism; while most maintained normal BMD, 13% displayed low BMD after 23.5 years of follow-up, indicating some risk among long-term survivors.
- - The study found that BMD remained stable over time for both those with and without permanent hypoparathyroidism, as bone turnover markers also showed consistent results throughout the follow-up period.
Article Synopsis
- - Differentiated thyroid carcinoma (DTC) in children is rare, but survivors have high survival rates; thus, it's crucial to study their long-term health effects, particularly concerning fertility.
- - The study analyzed reproductive characteristics and anti-Müllerian hormone (AMH) levels in female DTC survivors diagnosed before age 18 and found no significant fertility issues or premature menopause among them.
- - Out of 56 evaluated survivors, most had successful pregnancies, with 45 out of 64 reported pregnancies resulting in live births, and AMH levels were comparable to those of healthy women, indicating preserved ovarian function.
Context: Current guidelines do not consistently recommend imaging beyond the head and neck region in succinate dehydrogenase subunit D (SDHD) mutation carriers as long as catecholamine metabolite levels are within the reference range.
Participants: We report a series of 10 patients carrying pathogenic variants in the SDHD gene from five tertiary referral centers for paraganglioma (PGL) in the Netherlands, who presented with a sympathetic PGL (sPGL), pheochromocytoma (PHEO), or metastases outside the head and neck region in the absence of excessive catecholamine production. Two of six patients with a biochemically silent sPGL/PHEO developed metastatic disease.
Objective: The impact of childhood differentiated thyroid carcinoma (DTC) on psychosocial development has not yet been studied. The aim of this study was to evaluate the achievement of psychosocial developmental milestones in long-term survivors of childhood DTC.
Design And Methods: Survivors of childhood DTC diagnosed between 1970 and 2013 were included.
Introduction: Whether pediatric patients with differentiated thyroid carcinoma (DTC) are at risk of developing treatment-related adverse effects on cardiac function is unknown. We therefore studied in long-term survivors of pediatric DTC the prevalence of cardiac dysfunction and atrial fibrillation in relation to treatment variables, and the association between cardiac dysfunction and plasma biomarkers.
Methods: In this nationwide prospective multicenter study, cardiac assessments were performed in 66 adult survivors of pediatric DTC (age at diagnosis ≤18 years and follow-up ≥5 years after diagnosis) treated in the Netherlands between 1970 and 2009.
Article Synopsis
- The study investigates the long-term quality of life (QoL) of survivors of pediatric differentiated thyroid carcinoma (DTC) by comparing their health outcomes with matched controls.
- A total of 67 survivors, diagnosed when they were 18 or younger, completed various questionnaires to assess generic health-related QoL, fatigue, anxiety, and depression.
- While most QoL scores were similar between survivors and controls, survivors reported more physical issues and mental fatigue, indicating some mild impairments in specific QoL areas, with factors like unemployment linked to worse outcomes.
Article Synopsis
- Pediatric differentiated thyroid carcinoma (DTC) treatment relies mainly on adult studies due to limited pediatric data; this study evaluates the presentation, complications, and long-term outcomes in pediatric DTC patients in The Netherlands from 1970 to 2013.
- The study identified 170 patients, with a 99.4% overall survival rate after a median follow-up of 13.5 years; median age at diagnosis was 15.6 years, and 32.4% experienced life-long postoperative complications.
- The findings emphasize the need to prioritize reducing treatment-related morbidity and suggest centralizing care to improve outcomes and minimize adverse effects for children with pediatric DTC.
The present study tests the hypothesis that specific endocrine, metabolic, and anthropometric features distinguish obese women with polycystic ovary syndrome (PCOS) who resume ovulation in response to calorie restriction and weight loss from those who do not. Fifteen obese (body mass index 39 +/- 7 kg/m(2)) hyperandrogenemic oligoovulatory patients undertook a very low calorie diet (VLCD), wherein each lost > or =10% of body weight over a mean of 6.25 mo.
View Article and Find Full Text PDFObjective: To compare steroids and their associations in men with type 1 diabetes and healthy control subjects.
Research Design And Methods: We studied 52 adult men with type 1 diabetes without microvascular complications, compared with 53 control subjects matched for age and BMI. Steroids and their binding globulins were assessed in a single venous blood sample and a 24-h urine sample.
Obesity is associated with considerably reduced plasma GH concentrations, which may contribute to anovulation in (obese) women with polycystic ovary disease (PCOS). This clinical investigation was undertaken to establish whether the GH release process is deranged in obese women with PCOS and, if so, whether the observed anomalies are features of the syndrome or a sequel of body fat accretion. To this end we sampled 24-h plasma GH concentration profiles at 10-min intervals in 15 obese PCOS patients [mean age, 29 yr (range, 20-38); percent body fat, 47 +/- 5.
View Article and Find Full Text PDFWe hypothesized that short-term calorie restriction would blunt luteinizing hormone (LH) hypersecretion in obese women with polycystic ovary syndrome (PCOS) and thereby ameliorate the anovulatory endocrine milieu. To test this hypothesis, 15 obese patients with PCOS and nine age- and body mass index-matched healthy women underwent 24-h blood sampling to quantitate plasma LH, leptin, and insulin levels. PCOS subjects were prescribed a very low caloric liquid diet (4.
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