Publications by authors named "Eveline Roelofsen"
Introduction: Remdesivir is a registered treatment for hospitalised patients with COVID-19 that has moderate clinical effectiveness. Anecdotally, some patients' respiratory insufficiency seemed to recover particularly rapidly after initiation of remdesivir. In this study, we investigated if this rapid improvement was caused by remdesivir, and which patient characteristics might predict a rapid clinical improvement in response to remdesivir.
View Article and Find Full Text PDFObjectives: Prudent handling of reported antibiotic allergies is an important aspect of antibiotic stewardship. The Dutch Working Party on Antibiotic Policy (SWAB) constituted a multidisciplinary expert committee to provide evidence-based recommendations for bedside decision-making in antibiotic therapy in patients that report an antibiotic allergy.
Methods: The guideline committee generated 12 key questions, most of which were population, intervention, comparison, and outcome questions relevant to both children and adults with suspected antibiotic allergies.
Article Synopsis
- Flucloxacillin has been a long-standing treatment for methicillin-susceptible Staphylococcus aureus (MSSA), yet its pharmacodynamics are not fully understood.
- The study measured minimum inhibitory concentrations (MICs) of 305 MSSA isolates to establish wild-type distribution and tested the drug's effectiveness using a neutropenic mouse infection model.
- The findings revealed that maintaining flucloxacillin concentrations above certain thresholds (specifically, a percentage of time the unbound concentration remains above MIC) correlates with treatment efficacy, suggesting ways to optimize human dosing regimens.
Article Synopsis
- The study aimed to analyze how cefotaxime is processed in critically ill adult patients and identify optimal dosages for effective treatment against specific bacteria, namely Enterobacterales and Staphylococcus aureus.!* -
- By sampling 92 patients during drug intervals and using a 2-compartment model for pharmacokinetics, the research found that factors like kidney function and albumin levels significantly affect drug clearance.!* -
- The study concluded that dosing regimens of cefotaxime, specifically 1 g every 8 hours for Enterobacterales and continuous infusion of 6 g per 24 hours for S. aureus, are most effective based on patients’ kidney and albumin levels.!*
A survey of diagnosis and treatment of invasive aspergillosis was conducted in eight University Medical Centers (UMCs) and eight non-academic teaching hospitals in the Netherlands. Against a background of emerging azole resistance in Aspergillus fumigatus routine resistance screening of clinical isolates was performed primarily in the UMCs. Azole resistance rates at the hospital level varied between 5% and 10%, although rates up to 30% were reported in high-risk wards.
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