Helicobacter pylori prevalence and risk factors among children with celiac disease.

Background/aims: The relationship between Helicobacter pylori and celiac disease (CD) remains controversial. The aim of this study was to assess the prevalence and risk factors for H. pylori infection among children diagnosed with CD.

ATOPIC DERMATITIS--CLINICAL EPIDEMIOLOGY AND IMMUNOLOGICAL CORRELATIONS.

Aim: Medical records from 2010-2014 were retrospectively reviewed and analyzed in view of determining the correlations between the clinical severity of atopic dermatitis (AD) and total IgE level, eosinophilia, place of residence, family history of atopy, type of birth, and natural or artificial feeding.

Material And Methods: Following medical record review, 296 cases diagnosed with AD were included in the study. Statistical analysis was performed using SPSS v20 for determining the frequency and testing the hypotheses, for p < 0.

Coexistence of celiac disease and systemic lupus erythematosus in a 6-year-old girl-case report.

Systemic lupus erythematosus (SLE) is a serious and potentially fatal syndrome characterized by an autoimmune assault on various organs and systems that may include the skin, joints, central nervous system, heart and kidneys. Recent research shows that gluten sensitivity causes more than just celiac disease and gluten has been linked to numerous autoimmune conditions. We report here a 6-year-old girl presenting with malaise, abdominal pain, loss of appetite, abdominal distension.

Gut-liver axis and fibrosis in nonalcoholic fatty liver disease: an input for novel therapies.

Non-alcoholic fatty liver disease is a multifactorial condition, ranging from simple steatosis to non-alcoholic steatohepatitis with or without fibrosis. In non-alcoholic fatty liver disease, alteration of gut microbiota and increased intestinal permeability increase exposure of the liver to gut-derived bacterial products: lipopolysaccharides and unmethylated CpG DNA. These products stimulate innate immune receptors, namely Toll-like receptors, which activate signalling pathways involved in liver inflammation and fibrogenesis.

Risk factors and their implications in the epidemiology of pediatric obesity.

Unlabelled: Obesity is the most common food disorder in children from developed countries, its frequency alarmingly increasing in Romania.

Aim: To evaluate the epidemiological dynamics of obesity and associated risk factors.

Material And Methods: Retrospective and prospective study of 146 obese children admitted to the 2nd Iasi Pediatric Clinic between 2008-2012 aimed at evaluating the epidemiological dynamics of obesity and associated risk factors.

[Variability of nutritional status and of the parameters of lipid metabolism in gluten-free diet].

Unlabelled: Celiac disease is one of the most common forms of food intolerance in children, being an autoimmune enteropathy occurring in genetically susceptible individuals. The only treatment of celiac disease consists in a lifelong strict gluten-free diet. After gluten free diet patients with normal weight or growth failure risk become obese on the one hand because of recovery intestinal absorption and, on the other hand, nutritionally unbalanced diet, high in fat and protein.

[Liver involvement in celiac disease in children].

Unlabelled: Celiac disease (CD) is an autoimmune systemic enteropathy triggered by gluten intake in patients with genetic susceptibility, characterized by clinic polymorphism: classic forms, mainly with digestive features, and atypical forms, liver involvement being a part of them. In present, any unknown cytolysis requires screening serologic determinations for CD.

Aims: to assess the presence of liver manifestations in children diagnosed with CD, the outcome of liver function with gluten-free diet (GFD) and also to emphasize the importance of the immunological screening for CD in patients with unknown etiology liver dysfunctions.

Some implications of Scale Relativity theory in avascular stages of growth of solid tumors in the presence of an immune system response.

We present a traveling-wave analysis of a reduced mathematical model describing the growth of a solid tumor in the presence of an immune system response in the framework of Scale Relativity theory. Attention is focused upon the attack of tumor cells by tumor-infiltrating cytotoxic lymphocytes (TICLs), in a small multicellular tumor, without necrosis and at some stage prior to (tumor-induced) angiogenesis. For a particular choice of parameters, the underlying system of partial differential equations is able to simulate the well-documented phenomenon of cancer dormancy and propagation of a perturbation in the tumor cell concentration by cnoidal modes, by depicting spatially heterogeneous tumor cell distributions that are characterized by a relatively small total number of tumor cells.

[Chronic hepatitis C in children: are extrahepatic manifestations an argument for standard therapy?].

Unlabelled: Chronic hepatitis C is still an important health problem in children. Adequate management of those patients should be focused on two directions: disappearance or reduction of the viral load (conventional antiviral therapy) and treatment of autoimmune manifestations (corticoids, plasmapheresis, cytotoxic agents).

Aim: To associate extrahepatic manifestations with other disorders and to evaluate the evolution under specific (antiviral) and non-specific therapy.

[Chronic hepatitis B--still a problem in children].

Vaccination of the newborns and adolescents had impact on the incidence of acute and chronic infection with hepatitis B virus (HBV) in children. After a decade of this national program application, authors proposed to study the epidemiologic dynamics of chronic infection with HBV in this interval, compared with the previous period, prior to vaccination.

[Trends in epidemiological evolution of viral hepatitis B and C , in children , Romania and Iaşi county between 1990-2009].

Unlabelled: Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are the frequent causes of acute and chronic hepatitis worldwide and the leading causes for hepatic cirrhosis and liver cancer. There is a distinct geographical variation in VHB and VHC incidence in adult and child.

Aim: To assess the evolution trend of VHB and VHC incidence in child, in Romania and Iasi County, during the last two decades.

[Nutrition in cholestasis and long-term impact on trasnplant].

Aim: Plurietiological hepatic cholestasis involves an increased risk of protein-caloric malnutrition and specifical nutritional deficiencies. Biological investigations to determine deficiencies in fat-soluble vitamins are essential for specific nutritional therapy . Although malnutrition is not an absolute contraindication for liver transplantation, its gravity has complex consequences in relation to this intervention.

[Hepato-pulmonary syndrome].

The hepato-pulmonary syndrome (HPS) is a rare complication of liver cirrhosis, with poor outcome; the term includes liver disease, increased alveolo-arterial gradient and intrapulmonary vascular dilations, described by Fluckiger, Kennedy and Knudson. HPS impairs survival in cirrhotic patients and the posttransplant outcome is altered in correlation with severity of HPS. Combined determination of SaO2 in clino- and orthostatic position by a pulsoximeter is a simple test for HPS identification in patients with chronic liver disease or non-cirrhotic portal hypertension.

[Evaluation of quality of life in children with chronic hepatitis].

Unlabelled: The evolution of chronic viral and non-viral hepatitis in children, and the response to therapy influence the quality of life and the outcome of these patients and tehir family.

Material And Method: This study analyzes the quality of life in children with chronic liver disease, using the records of 45 patients hospitalised in the Hepatology Department of "Sf. Maria" Hospital of Children in Iaşi.

[X-linked Bruton congenital agammaglobulinemia. Case report].

Congenital agamaglobulinemia is a B-cell deficiency caused by tirosin-kinase gene mutations. This article presents the case of a 2 years and 6 months old boy with a history of multiple respiratory infections, which also associates a malabsorbtion syndrome. The patient presented for symptoms of arthritis.

[Structure and replication of viral hepatitis C virus, the key of the future therapeutic goals].

This paper reviews literature data on the hepatitis C virus. Hepatitis C virus is a positive-sense, single-stranded RNA virus. It is a genetically variable virus and it is estimated that the dominant viral sequence changes every few weeks.

[Osteopenia in children with juvenile idiopathic arthritis].

Unlabelled: The aim of the study was to evaluate the presence and etiopathogenesis of osteopenia in 41 children with Juvenile Idiopathic Arthritis (JIA).

Methods: Bone status was evaluated by quantitative ultrasound using a Sunlight Omnisense 7000s Ultrasound Bone Sonometer. Measurements were performed at the distal radius and midshaft tibia.

[Obesity in children: new controversies and present prevention measures].

The authors realise a synthesis on classical data and recent pathogenic explanations in childhood obesity. The obesity is a nutritional disorder of great interest nowadays and surpasses the incidence of the major problem of pediatrics until now--the malnutrition. There is documented data concerning the global incidence of obesity which is continuously growing when it comes to children.

Glycogen storage disease type I--between chronic ambulatory follow-up and pediatric emergency.

Background And Aims: To describe the characteristics of patients with type I glycogenosis, the presentation types, the main clinical signs, the diagnostic criteria and also the disease outcomes on long term follow-up.

Methods: The study group consisted of 6 patients (medium age 3 years 6 months) admitted in hospital between 2001 and 2005 and followed-up for 1 to 5 years. The sex ratio was 1:1.

[Turner's syndrome, diagnosis and therapeutical approach].

Turner's Syndrome is a rare chromosomal disorder of females (1 : 2500) characterized by short stature and the lack of sexual development at puberty. Other physical features may include a webbed neck, heart defects, kidney abnormalities, and/or various other malformations. Diagnosis should be considered in individuals with primary or secondary amenorrhea and adult women with unexplained infertility, particularly when such individuals also are short in stature.

[Metabolic abnormalities with hematologic manifestation].

These are unusual diseases in pediatric pathology. We present the morphologic aspects of peripheral blood smear and bone marrow smear of nine storage disease cases.

[Hemangioendothelioma in children].

The hemangioendothelium is a vascular tumor rarely seen in the pediatric practice. This case underlines the difficulty that lies in establishing a differential diagnosis with a localized adenopathy when this vascular tumor is developing inside a ganglionic region. The surgical treatment followed by interferon therapy determined a favorable evolution in this case because the hemangioendothelium is a vascular borderline tumor.

[Systemic lupus erythematosus in children. I: clinical and age dependent evolutive characteristics].

The individualized, retrospective study of 14 children with SLE (4-16 years) pointed out a series of clinical and age dependent evolutive characteristics. Below the age of 10 years old (lot 1:2 boys and 4 girls), SLE started as a prolonged fever syndrome (5-16 weeks) in the majority of cases; for 2 children the severe poliarthritis resistant to the AINS therapy is associated with the durable absence of the antinuclear seric antibody (ANA). For the same age group a high frequency of neurological manifestations (5/6 cases) was noticed.