Publications by authors named "Evelin Comelato"
J Bioenerg Biomembr
February 2008
Article Synopsis
- - Complex I in mitochondria mainly produces hydrogen peroxide (H2O2), with levels being low during NAD-linked substrate oxidation but high during succinate oxidation due to reverse electron flow.
- - This H2O2 production is considered physiological, occurring even at low succinate concentrations and in the presence of NAD substrates in heart and rat brain mitochondria.
- - Long-chain fatty acyl-CoAs inhibit succinate-dependent H2O2 release, and this inhibition is influenced by their unbound form and is independent of their oxidation, with effects being modulated by compounds like carnitine and malonyl-CoA.
