Publications by authors named "Eveillard M"
We aimed to describe the characteristics of teachers' engagement and persistence in an innovative multidisciplinary health programme. Participants in this descriptive and comprehensive study consisted of teachers in higher education (veterinary medicine, human medicine, pharmacy, engineers in husbandry) who were involved in the conception and the implementation of an international Master programme called MAN-IMAL. This programme was characterized by interculturality, multidisciplinarity, using technology, active teaching, and learning.
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- VEXAS syndrome, identified in 2020, is caused by mutations in the UBA1 gene and shows a variety of clinical and hematological features, making it challenging to distinguish from other inflammatory conditions. !* -
- This study collected a dataset of 9,514 images of polymorphonuclear cells (PMNs) and used a convolutional neural network (CNN) to automate the detection of specific dysplastic features unique to VEXAS, achieving a high level of accuracy (AUC of 0.85-0.97). !* -
- Results indicate that automated analysis can effectively support hematologists in identifying potential VEXAS cases, suggesting a screening score for UBA1 mutational
We identified a high prevalence (46.4%) of wound colonization with methicillin-resistant Staphylococcus aureus (MRSA) in patients hospitalized in a center devoted to the treatment of cutaneous tropical diseases in Benin. The proportion of MRSA among S aureus isolates was 54.
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- Acute leukaemias are serious blood cancers that require quick and accurate diagnosis of their three main types (ALL, AML, APL) to ensure proper treatment and reduce mortality risk, but expert diagnosis can be challenging due to resource limitations.
- Researchers aimed to develop a machine-learning model using routine laboratory data to identify leukaemia subtypes and improve diagnostic accuracy without the need for extensive cytological expertise.
- The study involved data from six French hospitals and successfully built the Artificial Intelligence Prediction of Acute Leukemia (AI-PAL) tool, which demonstrated strong performance in predicting leukaemia subtypes based on 19 selected laboratory parameters from the patient datasets.
For undergraduate pharmacy students, the first step of antimicrobial stewardship learning objectives is to integrate antimicrobial knowledge from the foundational sciences. We hypothesised that using a multidisciplinary approach including two sessions of tutorials could be relevant in term of students' interest, satisfaction and learning retention time. The evaluation of students' feelings was based on a questionnaire including different dimensions and three focus groups with four students.
View Article and Find Full Text PDFUnlabelled: The classical lineage of is the most prevalent clonal group associated with Buruli ulcer in humans. Its reservoir is strongly associated with the environment. We analyzed together 1,045 isolates collected from 13 countries on two continents to define the evolutionary history and population dynamics of this lineage.
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- The presence of donor Vγ9Vδ2 T-cells after haploidentical hematopoietic stem cell transplant (h-HSCT) is linked to better disease-free survival, as these cells can target tumor cells without triggering severe side effects.
- A clinical study assessed the safety of generating these T-cells by combining zoledronic acid (ZA) with interleukin-2 (IL-2), showing that the procedure is safe and successfully increases T-cell numbers in patients.
- The study's outcomes suggest potential for further research into using this immunotherapy to reduce relapse rates after h-HSCT, indicating that more extensive trials may come next.
Background: Thanks to an improved therapeutic regimen in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL), 5 year-overall survival now exceeds 90%. Unfortunately, the 25% of children who relapse have an initial poor prognosis, potentially driven by pre-existing or emerging molecular anomalies. The latter are initially and essentially identified by cytogenetics.
View Article and Find Full Text PDFIn France, hospital cell therapy units have not been authorised to routinely produce chimeric antigen receptor T lymphocytes (CAR-T cells), which would then be referred to as academic CAR-T cells. CAR-T cells are classified as advanced therapy medicinal products and correspond to genetically modified T lymphocytes ex vivo. The CAR-T cell production process is complex and requires scientific and technical expertise to meet the acceptance criteria of the pharmaceutical quality system.
View Article and Find Full Text PDFIn this monocentric prospective study, the influence on long-term outcomes of peripheral blood levels of monocytic-myeloid-derived suppressive cells (M-MDSC) was investigated in 56 patients with acute leukemia (myeloid = 47; lymphoid = 9) before and after (Days+60/+90) allogeneic hematopoietic stem cell transplantation (Allo-HSCT). A risk of relapse was found to be associated with a level of pregraft M-MDSC above 1.4% by ROC curve analysis.
View Article and Find Full Text PDFBackground: We aimed to identify patients at low risk of bloodstream infection (BSI) in the ED.
Methods: We derived and validated a prediction model to rule out BSI in the ED without the need for laboratory testing by determining variables associated with a positive blood culture (BC) and assigned points according to regression coefficients. This retrospective study included adult patients suspected of having BSI (defined by at least one BC collection) from two European ED between 1 January 2017 and 31 December 2019.
Article Synopsis
- In acute myeloid leukaemia (AML), interleukin-6 (IL-6) is linked to chemotherapy resistance and worse patient outcomes, prompting researchers to explore tocilizumab, an anti-IL-6 receptor monoclonal antibody, as a potential treatment in combination with standard chemotherapy.
- A phase 1 trial at Nantes University Hospital tested three escalating doses of tocilizumab in adults with newly diagnosed or relapsed AML, aiming to determine the maximum tolerated dose (MTD) while monitoring safety and treatment responses.
- Of the 12 patients treated, no significant toxicities related to tocilizumab were observed, nine out of ten evaluable patients had a positive response to the treatment, indicating
Background: The bleeding risk of patients with mild platelet function disorders is difficult to assess and their phenotype remains ill-explored.
Aim: This study was designed to establish a comprehensive biological phenotype of patients with mild platelet function disorders.
Methods: Twenty patients were included with persistent abnormal light transmission aggregometry (LTA).
Background: The clinical results following regenerative endodontic procedures (REPs) vary according to numerous parameters, including the presence of bacteria. This limitation reduces the indications for REPs and calls for the development of next generation antibacterial strategies (NGAS) providing alternatives to current antibacterial strategies (CAS) such as double or triple antibiotic paste (DAP/TAP) and (Ca(OH)2).
Objectives: The present scoping review aims to describe the current trends regarding the use of such strategies and highlight future perspectives.
Background: Unique blood culture (UBC) has been proposed to limit the number of venipuncture and to decrease the risk of BC contaminations (BCC) without affecting their yield. We hypothesized that a multi-faceted program based on UBC in the ICU may reduce the rate of contaminants with a similar performance for bloodstream infections (BSI) identification.
Methods: In a before and after design, we compared the proportion of BSI and BCC.
Background: Therapeutic options for CD19 relapses after anti-CD19 CAR-T cells are still debated; second infusion of anti-CD19 CAR-T cells, therapeutic antibodies, or targeted therapies can be discussed. Here, we explore the immunophenotyping and lysis sensitivity of CD19 ALL relapse after anti-CD19 CAR-T cells and propose different therapeutic options for such a high-risk disease.
Methods: Cells from successive B-ALL relapses from one patient were collected.