In medial temporal lobe epilepsy (MTLE), surgery can improve symptoms but may lead to memory decline, making it crucial to predict post-operative outcomes using fMRI tasks.
A study of 46 MTLE patients assessed the effectiveness of fMRI language tasks in predicting memory outcomes after surgery; results showed memory fMRI had higher sensitivity in detecting hippocampal activity.
Language fMRI, while less sensitive, provided better accuracy in predicting memory performance when hippocampal activation occurred, suggesting a need for combining both tasks to improve post-operative outcome predictions.