Publications by authors named "Eve Md Smith"
Article Synopsis
- This study focused on serum IFN-α2 as a potential marker for disease activity and flare prediction in juvenile systemic lupus erythematosus (jSLE).
- Researchers analyzed 222 serum samples from jSLE patients, healthy controls, and juvenile idiopathic arthritis patients to compare IFN-α2 levels across groups and assess its predictive value for disease flares.
- The results indicated that higher IFN-α2 levels were associated with active disease states and could predict flare risk in jSLE patients, suggesting its utility for monitoring and managing the condition.
Article Synopsis
- Some experts and patients worked together to create a set of important data to help study childhood lupus, a disease that affects children.
- They made two datasets: a Core Dataset with 46 necessary items and an Expanded Dataset with 26 extra items, to help gather more information.
- This new information will help researchers around the world study childhood lupus better by using the same important facts and details.
Introduction: Juvenile-onset systemic lupus erythematosus (JSLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Neuropsychiatric (NP) involvement is a severe complication, encompassing a heterogeneous range of neurological and psychiatric manifestations.
Methods: Demographic, clinical, and laboratory features of NP-SLE were assessed in participants of the UK JSLE Cohort Study, and compared to patients in the same cohort without NP manifestations.
Systemic lupus erythematosus (SLE) is a systemic autoimmune/inflammatory disease. Patients diagnosed with juvenile-onset SLE (jSLE), when compared to individuals with adult-onset SLE, develop more severe organ involvement, increased disease activity and greater tissue and organ damage. In adult-onset SLE, clinical characteristics, pathomechanisms, disease progression and outcomes do not only vary between individuals and age groups, but also ethnicities.
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