Publications by authors named "Eve Lauren"
Background: Individuals with cleft lip and/or palate (CL/P) may grow up with a visible facial difference, alongside speech and/or hearing challenges. Self-perceptions are stronger predictors of psychosocial adjustment than objective assessments, highlighting the importance of patient-reported outcome measures. Previously titled the Satisfaction with Appearance (SwA) questionnaire, the Cleft Hearing, Appearance and Speech Questionnaire (CHASQ) has been used in several countries to assess patient satisfaction, guide clinical decision-making, and conduct craniofacial research, but has lacked general population norms from which to draw comparisons.
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- The CYP19A1 gene in humans shows expression in various tissues, while the rodent version is mainly active in the gonads and brain.
- Researchers created a transgenic mouse with a piece of the human CYP19A1 gene linked to a luciferase reporter, revealing similar tissue expression patterns to humans.
- Findings indicate high luciferase activity in the urinary bladder and seminal vesicles, with promoter activity differences and an androgen-dependent expression in the seminal vesicles, signifying their role in male estrogen production.